Yeah. In my experiments, they can co-exist and sorta work. But, there is a chance for conflict and. when that happens in my experience, things can lock up. For now, I would recommend keeping to one active master on a bus.
When the 16n is a master, it does talk to all of the target devices it supports. That means that the multiple Ansible, TXo, and ER-301 all receive their own commands on fader move.